literature

from now on, i will read at least one article or book chapter on biomaterials, write down some comments after reading
literatures to read on Apr. 7, 2006
http://dx.doi.org/10.1016/S0142-9612(99)00242-2

Osteoblast adhesion on biomaterials
Author: Anselme K.1
Source: Biomaterials, Volume 21, Number 7, April 2000, pp. 667-681(15)
Publisher:Elsevier Science

Abstract:
The development of tissue engineering in the field of orthopaedic surgery is now booming. Two fields of research in particular are emerging: the association of osteo-inductive factors with implantable materials; and the association of osteogenic stem cells with these materials (hybrid materials). In both cases, an understanding of the phenomena of cell adhesion and, in particular, understanding of the proteins involved in osteoblast adhesion on contact with the materials is of crucial importance. The proteins involved in osteoblast adhesion are described in this review (extracellular matrix proteins, cytoskeletal proteins, integrins, cadherins, etc.). During osteoblast/material interactions, their expression is modified according to the surface characteristics of materials. Their involvement in osteoblastic response to mechanical stimulation highlights the significance of taking them into consideration during development of future biomaterials. Finally, an understanding of the proteins involved in osteoblast adhesion opens up new possibilities for the grafting of these proteins (or synthesized peptide) onto vector materials, to increase their in vivo bioactivity or to promote cell integration within the vector material during the development of hybrid materials.
Keywords: Osteoblast; Adhesion; Biomaterial; Tissue engineering
Language: English
Document Type: Review article
DOI: 10.1016/S0142-9612(99)00242-2
Affiliations: 1: Institut de Recherche sur les Maladies du Squelette, Institut Calot, Rue du Dr Calot, 62600 Berck sur mer cedex, , France